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Tirzepatide typically requires 2-3 weeks to reach steady state in your bloodstream, so initial appetite effects may not be dramatic immediately

Unlike some peptides, ipamorelin does not significantly raise cortisol or prolactin levels, which is advantageous for those concerned about unwanted side effects related to these hormones

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This makes it a "dual-agonist." So, while it does the same job as a GLP-1 drug like semaglutide, it has an extra layer of action on the GIP pathway, which is what makes it unique

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Some patients experience stronger hunger rebound than others due to baseline GIPR receptor sensitivity